2. Apoptosis
  3. Apoptosis Caspase Bcl-2 Family
  4. Apoptotic agent-3

Apoptotic agent-3 (compound 15f) 通过潜在的线粒体介导的 Bcl-2/Bax 通路和激活 caspase-3 途径促进凋亡。Apoptotic agent-3 具有抗增殖活性，可用于癌症研究。

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Apoptotic agent-3 Chemical Structure

Apoptotic agent-3 Chemical Structure

CAS No. : 2482310-23-4

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Apoptotic agent-3 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research[1].

IC50 & Target[1]

Caspase 3

 

Bcl-2

 

Bax

 

体外研究
(In Vitro)

Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2 MCF-7 and WI-38 cells (normal human cells) with IC50 values of 1.62, 1.46, 2.04 and 117.9 µM, respectively[1].
. Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptotic agent-3 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HepG-2 cells
Concentration: 1.46 μM
Incubation Time: 24 hours
Result: The percentage of cells in the G2-M phase increased while the percentage of cells in G1 phase and S phase decreased.

Apoptosis Analysis[1]

Cell Line: HepG-2 cells
Concentration: 1.46 μM
Incubation Time: 24 hours
Result: Increased the early apoptosis ratio from 0.69% to 8.25% and increased the late apoptosis ratio from 0.32% to 13.05%.
分子量

511.60

Formula

C31H21N5OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptotic agent-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptotic agent-32482310-23-4Apoptotic agent3Apoptotic agent 3ApoptosisCaspaseBcl-2 Familyapoptosisanticancercaspase-3Bcl-2BaxInhibitorinhibitorinhibit

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