2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. AR-R17779 hydrochloride

AR-R17779 hydrochloride 

目录号: HY-135483A 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

AR-R17779 hydrochloride 是一种有效和选择性的 nAChR 全激动剂，对 α7 和 α4β2 亚型的 Ki 直分别为 92 和 16000 nM。AR-R17779 hydrochloride 可以改善大鼠的学习和记忆能力。AR-R17779 hydrochloride 也具有抗焦虑活性。AR-R17779 hydrochloride 可通过激活抗炎胆碱能（迷走神经）途径减轻炎症。

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AR-R17779 hydrochloride Chemical Structure

AR-R17779 hydrochloride Chemical Structure

CAS No. : 178419-42-6

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规格 价格 是否有货 数量
1 mg ￥990
In-stock
5 mg ￥2295
In-stock
10 mg ￥3600
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

AR-R17779 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways[1][2][4].

IC50 & Target

IC50: 92 nM (α7-nAChR)[1]
体外研究
(In Vitro)

AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor[1].
AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AR-R17779 hydrochloride 相关抗体:
体内研究
(In Vivo)

AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction[3].
AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen[3]
Dosage: 1, 2.5, 5 mg/kg
Administration: I.p. twice daily from day 20 until day 26
Result: Ameliorated arthritis and delayed onset of disease.
Reduced erosive disease, cartilage degradation and synovial inflammation.
Reduced TNFα levels in plasma and synovial tissue.
分子量

218.68

Formula

C9H15ClN2O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 32 mg/mL (146.33 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.5729 mL 22.8645 mL 45.7289 mL
5 mM 0.9146 mL 4.5729 mL 9.1458 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥99.0%

COA (290 KB)

产品使用指南 (1538 KB)
参考文献

AR-R17779 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5729 mL 22.8645 mL 45.7289 mL 114.3223 mL
5 mM 0.9146 mL 4.5729 mL 9.1458 mL 22.8645 mL
10 mM 0.4573 mL 2.2864 mL 4.5729 mL 11.4322 mL
15 mM 0.3049 mL 1.5243 mL 3.0486 mL 7.6215 mL
20 mM 0.2286 mL 1.1432 mL 2.2864 mL 5.7161 mL
25 mM 0.1829 mL 0.9146 mL 1.8292 mL 4.5729 mL
30 mM 0.1524 mL 0.7621 mL 1.5243 mL 3.8107 mL
40 mM 0.1143 mL 0.5716 mL 1.1432 mL 2.8581 mL
50 mM 0.0915 mL 0.4573 mL 0.9146 mL 2.2864 mL
60 mM 0.0762 mL 0.3811 mL 0.7621 mL 1.9054 mL
80 mM 0.0572 mL 0.2858 mL 0.5716 mL 1.4290 mL
100 mM 0.0457 mL 0.2286 mL 0.4573 mL 1.1432 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR-R17779178419-42-6nAChRNicotinic acetylcholine receptorsα7learningmemoryanxiolyticinflammationInhibitorinhibitorinhibit

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目录号：
HY-135483A
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