2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. Aristolactam BIII

Aristolactam BIII是一种有效的 DYRK1A 抑制剂，体外抑制DYRK1A的激酶活性 (IC50=9.67 nM)。Aristolactam BIII 可逆转 DYRK1A 转基因 (TG) 小鼠源性成纤维细胞的增殖缺陷和ds样果蝇模型的神经和表型缺陷。

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Aristolactam BIII Chemical Structure

Aristolactam BIII Chemical Structure

CAS No. : 53948-10-0

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Aristolactam BIII 相关抗体

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查看 DYRK 亚型特异性产品:

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DYRK1 DYRK2 DYRK3 DYRK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-15 GI50
3.35 μM
Compound: 6
Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay
Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay
[PMID: 19394218]
HCT-15 GI50
3.74 μM
Compound: 6
Antiproliferative activity against human HCT15 cells by SRB assay
Antiproliferative activity against human HCT15 cells by SRB assay
[PMID: 19394218]
MES-SA GI50
2.7 μM
Compound: 6
Antiproliferative activity against human MESSA cells by SRB assay
Antiproliferative activity against human MESSA cells by SRB assay
[PMID: 19394218]
MES-SA/Dx5 GI50
2.82 μM
Compound: 6
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
[PMID: 19394218]
分子量

309.32

Formula

C18H15NO4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aristolactam BIII 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aristolactam BIII53948-10-0DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseDYRK1AproliferativefibroblastneurologicalInhibitorinhibitorinhibit

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