2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis Anti-infection
  3. STAT Apoptosis Antibiotic
  4. Ascochlorin

Ascochlorin  (Synonyms: Ilicicolin D)

目录号: HY-101021
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Ascochlorin (Ilicicolin D)，异戊二烯类抗生素。Ascochlorin 主要通过抑制 STAT3 信号级联介导其抗肿瘤作用。Ascochlorin 诱导细胞凋亡 (apoptosis)。具有抗炎活性。

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Ascochlorin Chemical Structure

Ascochlorin Chemical Structure

CAS No. : 26166-39-2

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规格 价格 是否有货 数量
2.5 mg 询价
500 μg 现货 3 - 4 周
1 mg 询价

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Ascochlorin 相关抗体

Top Publications Citing Use of Products

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STAT3 STAT5 STAT6 STAT1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity[1][2][3].

IC50 & Target[3]

STAT3

 

Apoptosis

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.9 μM
Compound: 7
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 34781681]
HepG2 IC50
0.9 μM
Compound: 7
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 34781681]
MDA-MB-231 IC50
2.2 μM
Compound: 12
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
[PMID: 34516133]
MDA-MB-468 IC50
1.1 μM
Compound: 12
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
[PMID: 34516133]
体外研究
(In Vitro)

Ascochlorin (Ilicicolin D) (10-50 μM; 24-72 hours) inhibits the viability of HepG2, HCCLM3 and Huh7 cells in a time and dose dependent manner[3].
Ascochlorin (50 μM; 48 hours) induces apoptosis in HCC cells[3].
Ascochlorin (1-50 μM) significantly suppresses the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and decreases the gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Ascochlorin inhibits the mRNA expression and the protein secretion of interleukin (IL)-1β and IL-6 but not tumor necrosis factor (TNF)-α in LPS-stimulated RAW 264.7 macrophage cells. Ascochlorin suppresses nuclear translocation and DNA binding affinity of nuclear factor-κB (NF-κB). Ascochlorin down-regulates phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) and p-p38[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ascochlorin 相关抗体:

Cell Viability Assay[3]

Cell Line: HepG2, HCCLM3, Huh7 cells
Concentration: 10, 25, 50 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibit the viability of three different HCC cell lines tested (HepG2, HCCLM3 and Huh7) in a time and dose dependent manner.

Western Blot Analysis[3]

Cell Line: HepG2 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited expression of the cell cycle regulator protein cyclin D1, the anti-apoptotic proteins Bcl-2, Mcl-1, survivin and XIAP, and the invasive gene product MMP-9.
体内研究
(In Vivo)

Ascochlorin (Ilicicolin D) (2.5-5 mg/kg; i.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31) inhibits tumor growth in an orthotopic HCC mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight week-old athymic balb/c nude female mice (HCCLM3-Luc2 tumors)[3]
Dosage: 2.5 mg/kg, 5 mg/kg
Administration: I.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31
Result: Induced significant inhibition of tumor growth.
分子量

404.93

Formula

C23H29ClO4
CAS 号
结构分类
初始来源

Ascochyta viciae
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ascochlorin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ascochlorin26166-39-2Ilicicolin DSTATApoptosisAntibioticCOX-2HepG2HCCcyclinviabilityathymicbalb/cnudemiceanti-inflammatorytumorInhibitorinhibitorinhibit

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