2. GPCR/G Protein
  3. LPL Receptor
  4. ASP1126

ASP1126 是选择性的、具有口服活性的鞘氨醇1-磷酸 (S1P) 的激动剂，对 hS1P1 和 hS1P3 的 EC50 值分别为 7.12 nM 和 517 nM。ASP1126可减少外周血淋巴细胞、初代T细胞、中央记忆T细胞和效应记忆T细胞的数量。ASP1126具有较好的安全性，具有应用于临床移植的潜力。

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ASP1126 Chemical Structure

ASP1126 Chemical Structure

CAS No. : 1228580-11-7

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规格 是否有货
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ASP1126 相关抗体

Top Publications Citing Use of Products

查看 LPL Receptor 亚型特异性产品:

查看所有亚型
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile[1].

IC50 & Target

EC50: 7.12 nM (hS1P1), 517 nM (hS1P3)[1].
体内研究
(In Vivo)

ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival[1].
ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively[1].
Dosage: 0.2 mg/kg, 1 mg/kg, 5 mg/kg.
Administration: Orally once daily for 14 days.
Result: Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).
分子量

581.93

Formula

C26H26ClF6NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ASP1126 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP11261228580-11-7ASP 1126ASP-1126LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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产品名称：
ASP1126
目录号：
HY-125881
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