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  5. Aspergillomarasmine A

Aspergillomarasmine A是一种天然的氨基多羧酸，具有对B类金属β-内酰胺酶（MBLs）的有效抑制活性。Aspergillomarasmine A通过去除一个催化的Zn2+辅因子来使MBLs失活。Aspergillomarasmine A作为选择性的Zn2+捕获剂，促使金属辅因子的解离，从而间接使NDM-1失活。Aspergillomarasmine A导致NDM-1的低亲和力结合位点失去Zn2+离子。Aspergillomarasmine A的作用使得缺Zn2+的NDM-1迅速降解，从而增强其作为β-内酰胺增强剂的效能。Aspergillomarasmine A的机制在不同的Zn2+螯合剂中具有广泛适用性。

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Aspergillomarasmine A Chemical Structure

Aspergillomarasmine A Chemical Structure

CAS No. : 3484-65-9

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Aspergillomarasmine A 相关抗体

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生物活性

Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators[1].

分子量

307.26

Formula

C10H17N3O8
CAS 号
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aspergillomarasmine A 相关分类

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Keywords:

Aspergillomarasmine A3484-65-9OthersInhibitorinhibitorinhibit

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