2. Apoptosis Stem Cell/Wnt JAK/STAT Signaling Immunology/Inflammation
  3. Apoptosis Caspase STAT Interleukin Related
  4. Atiprimod dimaleate

Atiprimod dimaleate  (Synonyms: Azaspirane dimaleate; SKF 106615-12 dimaleate; SKF 106615A12 dimaleate)

目录号: HY-13559A
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Atiprimod (Azaspirane) (dimaleate) 是一种抗增殖和抗血管生成剂，能够抑制癌细胞系的增殖。Atiprimod (dimaleate) 还会诱导细胞凋亡 (Apoptosis)，并激活 T84 结肠癌细胞中的 caspase-9 和 caspase-3。Atiprimod (dimaleate) 抑制 bFGF 和 VEGF 诱导的人脐静脉内皮细胞的增殖和迁移，导致脐带形成受到干扰。Atiprimod (dimaleate) 降低 IL-6 和 VEGF 的产生，并抑制 Stat3 的激活。

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Atiprimod dimaleate Chemical Structure

Atiprimod dimaleate Chemical Structure

CAS No. : 183063-72-1

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Other Forms of Atiprimod dimaleate:

Atiprimod dimaleate 相关抗体

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生物活性

Atiprimod (Azaspirane) (dimaleate) is an anti-proliferative and anti-angiogenic agent that inhibits proliferation of cancer cell lines. Atiprimod (dimaleate) also induces Apoptosis and activates both caspase-9 and caspase-3 in T84 colon carcinoma cells. Atiprimod (dimaleate) inhibits both bFGF and VEGF induced proliferation and migration of human umbilical vein endothelial cells, resulting in disruption of cord formation. Atiprimod (dimaleate) reduces production of IL-6, VEGF and inhibits activation of Stat3[1].

分子量

568.74

Formula

C30H52N2O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Atiprimod dimaleate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atiprimod dimaleate183063-72-1Azaspirane dimaleateSKF 106615-12 dimaleateSKF 106615A12 dimaleateApoptosisCaspaseSTATInterleukin RelatedILanti-proliferativeanti-angiogeniccancer cell linescaspase-9caspase-3T84 colon carcinoma cellsmigrationIL-6Stat3Inhibitorinhibitorinhibit

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