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ATV041 是一种具有口服活性的布洛芬 (HY-78131) 和核苷酸类似物。ATV041 改善了口服药代动力学 (PK) 谱和组织分布，且具有抗小鼠肝炎病毒 (MHV) 活性。ATV041 以剂量依赖性方式降低了病毒载量，组织损伤和病毒诱导的炎症。

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ATV041 Chemical Structure

ATV041 Chemical Structure

CAS No. : 2935937-67-8

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规格 是否有货
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Customer Review

ATV041 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner[1].

IC50 & Target

Mouse hepatitis virus (MHV)[1]
体外研究
(In Vitro)

ATV041 抑制 CCoV、FIPV 和 TGEV，EC50 值分别为 1.406 µM、7.34 µM 和 3.777 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATV041 相关抗体:
体内研究
(In Vivo)

ATV041 (200 mg/kg；口服；单剂量) 广泛且快速地分布在血浆、肝脏、肺部和肾脏组织中[1]。
ATV041 (10、50 和 200 mg/kg；口服；单剂量) 以剂量依赖性方式抑制肝脏和肺中的病毒复制。ATV041 下调 TNF-α、IL-1β、IL-6、IFN-γ 和 CXCL10 炎症因子的表达，改善了组织损伤[1]。
GS-441524 和布洛芬在 SD 大鼠中的药代动力学 (PK) 参数[1]
(GS-441524 和布洛芬由 ATV041 水解产生)

Analytes Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (µM/L) AUC0-∞ (h•µM/L) MRT0-∞ (h) F (%)
GS-441524 p.o. 25.0 4.98±3.57 0.67±0.29 7.75±1.58 22.6±2.34 3.16±1.21 60.31±0.06
GS-441524 i.v. 5.0 2.81±3.28 0.08±0.00 5.67±0.57 7.51±0.85 1.28±0.139 -
Ibuprofen p.o. 25.0 2.63±1.78 0.67±0.29 80.2±12 263±37 3.35±0.925 78.42±0.11
Ibuprofen i.v. 5.0 1.58±0.82 0.03±0.00 41.8±3.12 67.1±4.39 1.57±0.294 -

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1].
Dosage: 5 or 25 mg/kg.
Administration: Oral gavage or intravenous injection; single dose.
Result: Showed an oral activity and efficacy.
Animal Model: BALB/c mice[1].
Dosage: 10, 50 and 200 mg/kg.
Administration: Oral gavage; single dose.
Result: Improved tissue distribution and reduced viral load, tissue damage, virus-induced inflammation.
分子量

479.53

Formula

C25H29N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATV041 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATV0412935937-67-8ATV 041ATV-041OthersBALB/c miceSD ratsIbuprofenGS-441524Antiviral agentAntiinflammatoryInhibitorinhibitorinhibit

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目录号：
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