2. Anti-infection
  3. Beta-lactamase Bacterial Antibiotic
  4. Avibactam sodium dihydrate

Avibactam sodium dihydrate  (Synonyms: NXL-104 dihydrate)

目录号: HY-14879C
产品使用指南

摩尔计算器

Avibactam sodium (NXL-104) dihydrate 是一种共价的、可逆的非 β-内酰胺 β-内酰胺酶抑制剂 (β-lactamase) 抑制剂，抑制 β-lactamase TEM-1 和 CTX-M-15，IC50 分别为 8 nM 和 5 nM。

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Avibactam sodium dihydrate Chemical Structure

Avibactam sodium dihydrate Chemical Structure

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Avibactam sodium dihydrate 的其他形式现货产品:

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Other Forms of Avibactam sodium dihydrate:

Avibactam sodium dihydrate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 62 篇科研文献

Proliferation Assay

    Avibactam sodium dihydrate purchased from MCE. Usage Cited in: J Antimicrob Chemother. 2017 Jul 1;72(7):1930-1936.  [Abstract]

    Total β-lactamase activity for bacterial lysates is measured using the chromogenic substrate nitrocefin, with or without Avibactam at 4 mg/L. (b) GR20263 hydrolysis activity of different bacterial lysates is determined with or without Avibactam at 4 mg/L.

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    Metallo-β-lactamase

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    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Avibactam sodium (NXL-104) dihydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

    IC50 & Target

    IC50: 5 nM (CTX-M-15), 8 nM (TEM-1)[1]
    体外研究
    (In Vitro)

    Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases[2].
    Ceftazidime (HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 blaKPC-2 positive and 1 of blaOXA-232 positive Klebsiella pneumonia growth with MIC50 and MIC90 for both 8 mg/L[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Avibactam sodium dihydrate 相关抗体:
    体内研究
    (In Vivo)

    Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model[3].
    Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model[4]
    Dosage: 0.375 mg/g in combination with Ceftazidime
    Administration: Subcutaneous injection, 4 h post infection and given every 8 h for 10 days
    Result: 70% of infection group mice died within 4 days, and all mice in the PBS group died within 13 days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8 h, whereas 100% of mice in this group died within 4 days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.
    Clinical Trial
    分子量

    323.26

    Formula

    C7H14N3NaO8S
    中文名称

    阿维巴坦钠二水合物
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Avibactam sodium dihydrate 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Avibactam sodium dihydrateNXL-104 dihydrate阿维巴坦钠二水合物Beta-lactamaseBacterialAntibioticβ-lactamaseTEM-1CTX-M-15antibacterialKlebsiella pneumoniaPseudomonas aeruginosaInhibitorinhibitorinhibit

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