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  4. AY 9944

AY 9944 是一种特异的胆固醇生物合成 (cholesterol biosynthesis) 抑制剂。AY 9944 抑制 7- 脱氢胆固醇 Δ7- 还原酶 (DHCR7) 酶，其 IC50 值为 13 nM。AY 9944 引起胆固醇不足和 7DHC 积累。在高剂量下，AY 9944 也可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶，这会导致胆固醇 8-en-3β-ol 的积累。

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AY 9944 Chemical Structure

AY 9944 Chemical Structure

CAS No. : 366-93-8

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规格 价格 是否有货 数量
1 mg ￥454
In-stock
5 mg ￥1000
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10 mg ￥1700
In-stock
25 mg ￥3500
In-stock
50 mg ￥5500
In-stock
100 mg 现货 询价
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500 mg   询价  

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Customer Review

Other Forms of AY 9944:

AY 9944 相关抗体

Top Publications Citing Use of Products

    AY 9944 purchased from MCE. Usage Cited in: Antiviral Res. 2022 Dec 15;209:105497.  [Abstract]

    Pretreatment with AY9944 (15, 30 µM), U18666A, lovastatin and MβCD for 2 h can all significantly reduce the level of EV-A71 VP1 protein in HCT-8 cell.

    AY 9944 purchased from MCE. Usage Cited in: Antiviral Res. 2022 Dec 15;209:105497.  [Abstract]

    AY9944 (30 μМ; 2 h) significantly inhibits the expression of EV-A71 VP1 protein in HCT-8 and RD cells.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3].

    IC50 & Target

    IC50: 13 nM (DHCR7)1
    体外研究
    (In Vitro)

    AY 9944 (1 μg/mL；15 h) 影响角质形成细胞中游离甾醇的类型[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    AY 9944 相关抗体:

    Cell Viability Assay[2]

    Cell Line: Human foreskin keratinocytes
    Concentration: 1 μg/mL
    Incubation Time: 15 hours
    Result: Inhibited the synthesis of cholesterol and desmosterol, but increased 7-dehydrocholesterol and zymosterol synthesis.
    体内研究
    (In Vivo)

    AY 9944 (7.5 mg/kg；从产后第 2 天到产后第 20 天，每 6 天一次 ih) 在停止治疗后 400 天内降低脑胆固醇[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Long–Evans hooded rats[3].
    Dosage: 7.5 mg/kg
    Administration: Subcutaneous injection; 7.5 mg/kg every 6 days once; from postnatal day 2 to postnatal day 20
    Result: Reduced brain cholesterol and increased 7-dehydrocholesterol in all brain regions of rats till the treatment stopped for 400 days and showed a more severe effect on the change of sterols in plasma and liver of female rats.
    分子量

    464.30

    Formula

    C22H30Cl4N2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 5 mg/mL (10.77 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    H2O 中的溶解度 : 5 mg/mL (10.77 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.1538 mL 10.7689 mL 21.5378 mL
    5 mM 0.4308 mL 2.1538 mL 4.3076 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.67%

    COA (282 KB) LCMS (89 KB)

    产品使用指南 (1538 KB)
    参考文献

    AY 9944 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.1538 mL 10.7689 mL 21.5378 mL 53.8445 mL
    5 mM 0.4308 mL 2.1538 mL 4.3076 mL 10.7689 mL
    10 mM 0.2154 mL 1.0769 mL 2.1538 mL 5.3844 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AY 9944366-93-8AY9944AY-9944Otherscholesterolreductasebiosynthesis7DHCaccumulationΔ7-Δ8isomerasehypocholesterolemiaInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
    HY-107420
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