2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  3. Calcium Channel Sodium Channel SARS-CoV
  4. Bepridil

Bepridil  (Synonyms: (±)-Bepridil; Org 5730)

目录号: HY-16952
产品使用指南

摩尔计算器

Bepridil ((±)-Bepridil) 是一种钙离子通道 (calcium channel) 阻滞剂，用于抗心律失常。Bepridil 对钙、钠电流均有抑制作用，在某些缺血性室性心律失常中具有研究潜力。Bepridil 对 SARS-CoV-2 进入 Vero E6 和 A549 细胞内复制也有较强的抑制作用。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Bepridil hydrochloride 和 Bepridil hydrochloride hydrate 通常具有更好的水溶性和稳定性。

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Bepridil Chemical Structure

Bepridil Chemical Structure

CAS No. : 64706-54-3

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Bepridil 的其他形式现货产品:

Customer Review

Other Forms of Bepridil:

Bepridil 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

查看 Sodium Channel 亚型特异性产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2].

IC50 & Target

Calcium channel, Sodium channel, SARS-CoV-2[1][2]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Astrocyte EC50
4.724 μM
Compound: 28
Antiproliferative activity against mouse astrocyte cells by MTT assay
Antiproliferative activity against mouse astrocyte cells by MTT assay
[PMID: 17417631]
CHO IC50
1 μM
Compound: bepridil
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
[PMID: 23812503]
HEK293 IC50
1.4 μM
Compound: Bepridil
Inhibition of human ERG expressed in HEK293 cells measured after 30 mins by FluxOR dye based FLIPR TETRA assay
Inhibition of human ERG expressed in HEK293 cells measured after 30 mins by FluxOR dye based FLIPR TETRA assay
[PMID: 32392053]
HEK293 IC50
1.4 μM
Compound: Bepridil
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
[PMID: 22761000]
HEK293 IC50
3700 nM
Compound: Bepridil
Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA
Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA
[PMID: 21300721]
RAW264.7 IC50
4.8 μM
Compound: Bepridil
Protection against Bacillus anthracis lethal toxin-mediated cytotoxicity in mouse RAW264.7 cells assessed as change in viability after 24 hrs by WST1 dye reduction assay
Protection against Bacillus anthracis lethal toxin-mediated cytotoxicity in mouse RAW264.7 cells assessed as change in viability after 24 hrs by WST1 dye reduction assay
[PMID: 17485504]
Ventricular myocyte IC50
0.211 μM
Compound: Bepridil
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
[PMID: 22761000]
Ventricular myocyte IC50
0.5 μM
Compound: Bepridil
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
[PMID: 22761000]
Ventricular myocyte IC50
2.6 μM
Compound: Bepridil
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
[PMID: 22761000]
Ventricular myocyte IC50
211 nM
Compound: Bepridil
Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes
Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes
[PMID: 21300721]
分子量

366.54

Formula

C24H34N2O
CAS 号
中文名称

苄普地尔
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bepridil 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bepridil64706-54-3(±)-Bepridil Org 5730苄普地尔Org5730Org 5730Org-5730Calcium ChannelSodium ChannelSARS-CoVCa2+ channelsCa channelsNa channelsNa+ channelsSARS coronavirusAntivirusantiarrhythmicSARS-CoV-2Inhibitorinhibitorinhibit

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