2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Bethanidine sulfate

Bethanidine sulfate  (Synonyms: BW 467C60)

目录号: HY-16094
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Bethanidine sulfate 及其邻位氯衍生物 (BW 392C60) 是强效肾上腺素能神经元阻滞剂，在各种动物模型（尤其是猫）中具有与溴苄胺和胍乙啶类似的拟交感神经作用。它们抑制神经刺激期间去甲肾上腺素的释放，并增强平滑肌对肾上腺素和去甲肾上腺素的反应。Bethanidine sulfate 可增加对酪胺的升压反应，但这种作用会随着剂量的增加而减弱。与胍乙啶不同，Bethanidine sulfate 在给药后不会消耗猫虹膜中的升压胺含量。它还会短暂抑制自主胆碱能机制，并在大剂量时导致暂时性神经肌肉麻痹，与其长期的肾上腺素能神经元阻滞作用形成对比。

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Bethanidine sulfate Chemical Structure

Bethanidine sulfate Chemical Structure

CAS No. : 114-85-2

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Bethanidine sulfate 相关抗体

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α adrenergic receptor β adrenergic receptor

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生物活性

Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neurone blockers with sympathomimetic effects similar to bretylium and guanethidine in various animal models, particularly in cats. They inhibit the release of noradrenaline during nerve stimulation and enhance smooth muscle responses to adrenaline and noradrenaline. Bethanidine sulfate increases pressor responses to tyramine, though this effect diminishes with higher doses. Unlike guanethidine, Bethanidine sulfate does not deplete pressor amine content in the iris of cats post-administration. It also briefly inhibits autonomic cholinergic mechanisms and causes temporary neuromuscular paralysis in large doses, contrasting with its prolonged adrenergic neurone blocking effects[1].

分子量

275.32

Formula

C10H17N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bethanidine sulfate 相关分类

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Keywords:

Bethanidine114-85-2BW 467C60Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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