2. Immunology/Inflammation
  3. FLAP
  4. BI 665915

BI 665915 是具有口服活性且强效的 5-脂氧酶激活蛋白 (FLAP) 抑制剂。BI 665915 抑制 FLAP 的生成，从而阻止小鼠体内 LTB4 的生物合成。BI 665915 有望用于各种炎症性疾病，包括呼吸系统和心血管疾病的研究。

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BI 665915 Chemical Structure

BI 665915 Chemical Structure

CAS No. : 1360550-04-4

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规格 是否有货
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BI 665915 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BI 665915 is an orally active and potent 5-lipoxygenase-activating protein (FLAP) inhibitor. BI 665915 inhibits FLAP production that blocks LTB4 biosynthesis in mice. BI 665915 is promising for research of various inflammatory diseases, including respiratory and cardiovascular diseases[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
1.7 nM
Compound: 69, BI665915
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis
[PMID: 25671290]
分子量

458.52

Formula

C24H26N8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BI 665915 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI 6659151360550-04-4BI665915BI-665915FLAP5-lipoxygenase-activating protein5-LO activating proteinorally activemiceinflammatory diseasesInhibitorinhibitorinhibit

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目录号：
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