2. GPCR/G Protein
  3. Leukotriene Receptor
  4. BIIL-260

BIIL-260 是一种有效的具有口服活性白三烯 B(4) 受体 (LTB4) 的拮抗剂，有抗炎活性，是前药 BIIL 284 的活性代谢产物。BIIL-260 以可逆与竞争性方式与 LTB4 受体相互作用，对分离的人嗜中性粒细胞膜上的 LTB4 受体具有高亲和力，Ki 值为 1.7 nM。

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BIIL-260 Chemical Structure

BIIL-260 Chemical Structure

CAS No. : 204974-93-6

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规格 是否有货
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BIIL-260 的其他形式现货产品:

Customer Review

Other Forms of BIIL-260:

BIIL-260 相关抗体

Top Publications Citing Use of Products

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with the Ki value of 1.7 nM[1].

IC50 & Target

Ki: 1.7 nM (LTB4 receptor)[1]
体外研究
(In Vitro)

BIIL-260 potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with the IC50 value of 0.82 nM.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BIIL-260 相关抗体:
分子量

466.57

Formula

C30H30N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BIIL-260 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIIL-260204974-93-6BIIL260BIIL 260Leukotriene ReceptorInhibitorinhibitorinhibit

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产品名称：
BIIL-260
目录号：
HY-114641
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