2. Epigenetics TGF-beta/Smad Apoptosis
  3. PKC Apoptosis
  4. Bisindolylmaleimide VIII

Bisindolylmaleimide VIII  (Synonyms: Ro 31-7549; Bis VIII)

目录号: HY-129624
产品使用指南

摩尔计算器

Bisindolylmaleimide VIII (Ro 31-7549) 是一种有效的选择性蛋白激酶 C (PKC) 抑制剂，对大鼠脑 PKC 的 IC50 为 158 nM。Bisindolylmaleimide VIII 对 PKC-α，PKC-βI，PKC-βII，PKC-γ，PKC-ε 的 IC50 分别为 53、195、163、213 和 175 nM。Bisindolylmaleimide VIII 促进 Fas 介导的细胞凋亡 (apoptosis)，并抑制 T 细胞介导的自身免疫性疾病。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Bisindolylmaleimide VIII Chemical Structure

Bisindolylmaleimide VIII Chemical Structure

CAS No. : 125313-65-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Bisindolylmaleimide VIII 的其他形式现货产品:

Other Forms of Bisindolylmaleimide VIII:

Bisindolylmaleimide VIII 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bisindolylmaleimide VIII (Ro 31-7549) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively[1]. Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases[1][2].

IC50 & Target

Rat Brain PKC

158 nM (IC50)

PKCα

53 nM (IC50)

PKC-βI

195 nM (IC50)

PKC-βII

163 nM (IC50)

PKCγ

213 nM (IC50)

PKCε

175 nM (IC50)

体外研究
(In Vitro)

Bisindolylmaleimide VIII (5 μM; 8, 12 hours) 显著增加 TRA-8 诱导的细胞死亡，呈时间依赖性和剂量依赖性[2]。
Bisindolylmaleimide VIII (5 μM; 6 hours) 与 TRA-8 联合处理后，4 h procaspase-8 显著降低，6 h完全消失[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bisindolylmaleimide VIII 相关抗体:

Western Blot Analysis[2]

Cell Line: 1321N1 cells
Concentration: 5 μM
Incubation Time: 6 hours
Result: Significantly decreased procaspase-8 at 4 h and completely disappeared at 6 h.

Apoptosis Analysis[2]

Cell Line: 1321N1 cells
Concentration: 5 μM
Incubation Time: 8, 12 hours
Result: Dramatically increased TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners.
体内研究
(In Vivo)

Bisindolylmaleimide VIII (100 μg;i.p;每隔一天服用三次)，结合 toTRA-8，肿瘤几乎完全消退。单独使用 Bisindolylmaleimide VIII未引起肿瘤明显消退[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8-week-old female NOD/SCID mice[2].
Dosage: 100 μg
Administration: i.p.; every other day for three doses
Result: Resulted in nearly complete tumor regression combined toTRA-8.
分子量

398.46

Formula

C24H22N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bisindolylmaleimide VIII 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bisindolylmaleimide VIII125313-65-7Ro 31-7549 Bis VIIIPKCApoptosisProtein kinase CproteinkinaseCFasT cell-mediatedautoimmunediseasesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Bisindolylmaleimide VIII
目录号：
HY-129624
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z