2. Neuronal Signaling GPCR/G Protein Others
  3. 5-HT Receptor Dopamine Receptor Others
  4. BMY 28674

BMY 28674  (Synonyms: 6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528215)

目录号: HY-100057
产品使用指南

摩尔计算器

BMY 28674 (6-Hydroxybuspirone) 是抗焦虑丁螺环酮的活性代谢物。它由丁螺环酮通过细胞色素 P450 (CYP) 同工酶 CYP3A4.4 形成。BMY 28674 与大鼠海马和背缝中的血清素 (5-HT) 受体亚型 5-HT1A 结合（EC50s 分别为 4 和 1 μM），是多巴胺 D2、D3 和 D4 受体拮抗剂（IC50s 分别为 3.1、4.9 和 0.85 μM）。它还以浓度依赖性方式抑制 S2 近端小管细胞中表达人类转运蛋白的有机阳离子转运蛋白 1 (OCT1)、OCT2 和 OCT3。

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BMY 28674 Chemical Structure

BMY 28674 Chemical Structure

CAS No. : 125481-61-0

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Other Forms of BMY 28674:

BMY 28674 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone. It is formed from buspirone via the cytochrome P450 (CYP) isozyme CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). It also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.

IC50 & Target

Rat 5-HT1A Receptor

4 μM (EC50)

D2 Receptor

3.1 μM (IC50)

D3 Receptor

4.9 μM (IC50)

D4 Receptor

0.85 μM (IC50)

Rat 5-HT1A Receptor

1 μM (EC50)

分子量

401.50

Formula

C21H31N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMY 28674 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMY 28674125481-61-06-Hydroxybuspirone 6'-Hydroxybuspirone BMS 528215BMY28674BMY-28674BMS528215BMS 528215BMS-5282155-HT ReceptorDopamine ReceptorOthersSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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