BN-82451 dihydrochloride 

BN-82451 dihydrochloride, an orally active and CNS-penetrated antioxidant and a multitargeting neuroprotective agent, exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis^[1][2].

BN82451 对 COX-1 和 COX-2 的 IC₅₀ 值分别为0.08 和0.05 µM^[2]。
BN82451 通过神经元死亡的三个主要途径起作用:兴奋性毒性、氧化应激和炎症，也是线粒体保护^[2]。
BN82451 抑制大鼠脑微粒体脂质过氧化作用呈浓度依赖性，IC₅₀ 值为0.54 µM^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BN-82451 可改善亨廷顿氏病 (HD) 小鼠模型的运动能力和减轻神经退行性变。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

391.40

C₁₈H₂₈Cl₂N₂OS

663172-95-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Anthony J Hannan, et al. Novel therapeutic targets for Huntington's disease. Expert Opin Ther Targets. 2005 Aug;9(4):639-50.  [Content Brief]

  [2]. Pierre Etienne Chabrier, et al. Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent. CNS Drug Rev. 2007 Fall;13(3):317-32.  [Content Brief]