2. Anti-infection Apoptosis
  3. Antibiotic Apoptosis
  4. Boanmycin

Boanmycin 是一种具有抗肿瘤活性的抗生素，可以诱导细胞衰老、凋亡 (apoptosis)。

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Boanmycin Chemical Structure

Boanmycin Chemical Structure

CAS No. : 37293-17-7

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Boanmycin 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].

体外研究
(In Vitro)

Boanmycin (50-125 μg/mL, 0.5-36 h) can induce apoptosis and block the cell cycle in the G2/M phase in Eca-109 cells[2].
Boanmycin (6.7 µg/mL, 24 h) induces cell senescence[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Boanmycin 相关抗体:

Cell Viability Assay[3]

Cell Line: Human lung fibroblast cell line IMR90, mouse primary osteoblasts (OBs)
Concentration: 6.7 µg/mL
Incubation Time: 24 hours
Result: Showed a 90% positive number of SA-βgal stained cells in IMR90 cells and 95% in OBs compared to 30% in the control group.

RT-PCR[3]

Cell Line: Mouse primary osteoblasts (OBs)
Concentration: 6.7 µg/mL
Incubation Time: 24 hours
Result: Increased senescence-associated secretory phenotype (SASP) factor IL-6 expression up to six-fold.
体内研究
(In Vivo)

Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks) can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice with HT-29 or Hce-8693 cells[1]
Dosage: 10 or 15 mg/kg
Administration: Intraperitoneal injection; twice a week; 5 weeks
Result: Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model.
Animal Model: BALB/c nude mice with CT-26 cells[1]
Dosage: 10 mg/kg
Administration: Intramuscular injection; every second day; 10 times
Result: Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%.
Clinical Trial
分子量

1497.66

Formula

C60H96N20O21S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Boanmycin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boanmycin37293-17-7AntibioticApoptosisantibioticantitumorapoptosissenescenceInhibitorinhibitorinhibit

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