2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Breast cancer targeting peptide 18–4

Breast cancer targeting peptide 18–4 

目录号: HY-P10790
产品使用指南 技术支持

Breast cancer targeting peptide 18–4 是一种角蛋白 1 (KRT1) 受体靶向肽，Kd 为 0.98 μM。Breast cancer targeting peptide 18–4 的氨基酸序列为 WxEAAYQrFL，是 P160 peptide (HY-P10789) 类似物。Breast cancer targeting peptide 18–4 与抗癌肽 MccJ25 共价结合后能够显著增加 MccJ25 在乳腺癌细胞中的摄取率，并提高其抗癌活性。该共价结合物对 MCF-7、MDA-MB-435、MDA-MB-435-MDR 的 IC50 分别为 14.2、20、25 μM。

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Custom Peptide Synthesis

Breast cancer targeting peptide 18–4 Chemical Structure

Breast cancer targeting peptide 18–4 Chemical Structure

CAS No. : 1332850-08-4

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Breast cancer targeting peptide 18–4 相关抗体

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生物活性

Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide, with a Kd of 0.98 μM. The amino acid sequence of Breast cancer targeting peptide 18–4 is WxEAAYQrFL, and it is an analogue of P160 peptide (HY-P10789). When covalently conjugated with the anticancer peptide MccJ25, Breast cancer targeting peptide 18–4 significantly increases the cellular uptake of MccJ25 in breast cancer cells and enhances its anticancer activity. The covalent conjugate exhibits IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cells, respectively[1].

分子量

1296.47

Formula

C63H89N15O15
CAS 号
Sequence

Trp-{d-Nle}-Glu-Ala-Ala-Tyr-Gln-{d-Arg}-Phe-Leu
Sequence Shortening

W-{d-Nle}-EAAYQ-{d-Arg}-FL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Breast cancer targeting peptide 18–4 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Breast cancer targeting peptide 18–41332850-08-4Microtubule/TubulinInhibitorinhibitorinhibit

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