2. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK Apoptosis
  3. HDAC c-Met/HGFR Apoptosis
  4. c-Met/HDAC-IN-2

c-Met/HDAC-IN-2 是一种高效的 c-Met 和 HDAC 双重抑制剂，对 HDAC1 与 c-Met 的 IC50 分别为 18.49 nM 和 5.40 nM。c-Met/HDAC-IN-2 对几种癌细胞具有抗增殖活性。c-Met/HDAC-IN-2 能将 HCT-116 细胞周期阻滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。c-Met/HDAC-IN-2 可用于抗癌耐药研究。

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c-Met/HDAC-IN-2 Chemical Structure

c-Met/HDAC-IN-2 Chemical Structure

CAS No. : 2740495-53-6

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c-Met/HDAC-IN-2 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance[1].

IC50 & Target[1]

HDAC1

18.49 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.22 μM
Compound: 14x
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 32738414]
HCT-116 IC50
0.22 μM
Compound: 14x
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 32738414]
MCF7 IC50
1.59 μM
Compound: 14x
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 32738414]
体外研究
(In Vitro)

c-Met/HDAC-IN-2 (compound 14X) (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) induces of cancer cell apoptosis in a dose-dependent manner[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) significantly causes G2/M-phase arrest in HCT-116 cells in a dose dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

c-Met/HDAC-IN-2 相关抗体:

Cell Proliferation Assay

Cell Line: HCT-116, MCF-7 and A549[1]
Concentration: 0-20 μM
Incubation Time: 72 hours
Result: Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC50s of 0.22 ± 0.09 μM, 1.59 ± 0.06 μM and 0.22 ± 0.04 μM, respectively.

Apoptosis Analysis

Cell Line: HTC-116[1]
Concentration: 0.2, 1 and 5 μM
Incubation Time: 48 hours
Result: The percentage of apoptotic cells was 4.19%, 11.53% and 21.48% at 0.2 μM, 1.0 μM and 5.0 μM, respectively.

Cell Cycle Analysis

Cell Line: HTC-116[1]
Concentration: 0.2, 1 and 5 μM
Incubation Time: 48 hours
Result: Significantly caused G2/M-phase arrest in HCT-116 cells in a dose dependent manner.
分子量

623.66

Formula

C34H33N5O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

c-Met/HDAC-IN-2 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met/HDAC-IN-22740495-53-6HDACc-Met/HGFRApoptosisHistone deacetylasesAnticancerAntiproliferative activitiesHCT-116MCF-7A549Inhibitorinhibitorinhibit

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