2. Apoptosis
  3. c-Myc Apoptosis
  4. c-Myc inhibitor 15

c-Myc inhibitor 15 (Compound A5) 是一种选择性 c-Myc 抑制剂，通过破坏 c-Myc 和 Max 的相互作用来发挥抗癌功能，导致 c-Myc 蛋白降解并诱导凋亡 (Apoptosis)。其在 A549 和 NCI–H1299 肺癌细胞系中的 IC50 分别为 4.08 μM 和 7.86 μM，表现出强大的细胞毒性活性。c-Myc inhibitor 15 在同种异体肿瘤模型中表现出出色的抗肿瘤效果，肿瘤生长抑制率达到 76.4%，并显著降低了 c-Myc 蛋白的表达水平。c-Myc inhibitor 15 有望用于与 c-Myc 相关的肺癌研究。

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c-Myc inhibitor 15 Chemical Structure

c-Myc inhibitor 15 Chemical Structure

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c-Myc inhibitor 15 相关抗体

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  • 生物活性

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生物活性

c-Myc inhibitor 15 (Compound A5) is a selective c-Myc inhibitor that exerts anticancer effects by disrupting the interaction between c-Myc and Max, leading to the degradation of c-Myc protein and the induction of apoptosis. Its IC50 values are 4.08 μM and 7.86 μM in A549 and NCI-H1299 lung cancer cell lines, respectively, demonstrating strong cytotoxic activity. In a syngeneic tumor model, c-Myc inhibitor 15 exhibited outstanding antitumor efficacy, achieving a tumor growth inhibition rate of 76.4% and significantly reducing c-Myc protein expression levels. c-Myc inhibitor 15 holds promise for research related to c-Myc-driven lung cancers[1].

分子量

457.57

Formula

C27H31N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

c-Myc inhibitor 15 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

c-Myc inhibitor 15c-MycApoptosisMyc新品上线，张雨新分子推荐20241119;c-Myc inhibitor exhibited robust in vivo antitumor efficacy;https://www.sciencedirect.com/science/article/abs/pii/S022352342400905X(Compound A5)Inhibitorinhibitorinhibit

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