2. PROTAC Neuronal Signaling
  3. CaMK PROTACs
  4. CaMKIIα-PHOTAC

CaMKIIα-PHOTAC 是一种光化学靶向嵌合体 (PHOTAC)，靶向 Ca2+/钙调蛋白依赖性蛋白激酶 II α (CaMKIIα)。PHOTAC 这类分子能够在特定波长的光照下，通过内源蛋白酶体催化靶蛋白的泛素化和降解。CaMKIIα-PHOTAC 可降低降低突触功能，光条件下，它削弱了在小鼠海马区域的诱发场兴奋性突触后电位对生理刺激的反应强度。CaMKIIα-PHOTAC 对维持亚细胞树突结构域的长时程增强和记忆能力具有关键作用。

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CaMKIIα-PHOTAC Chemical Structure

CaMKIIα-PHOTAC Chemical Structure

CAS No. : 2481744-33-4

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CaMKIIα-PHOTAC 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains[1].

IC50 & Target

CaMKIIα[1]
分子量

1094.00

Formula

C54H58Cl2N10O11
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CaMKIIα-PHOTAC 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CaMKIIα-PHOTAC2481744-33-4CaMKPROTACsCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesCAMKIIαPHOTACselectrophysiologyimmunohistochemistryprotein homeostasissynaptic functionInhibitorinhibitorinhibit

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