2. Anti-infection
  3. Reverse Transcriptase HIV
  4. Capravirine

Capravirine  (Synonyms: S-1153)

目录号: HY-14294
产品使用指南

摩尔计算器

Capravirine (S-1153) 是具有口服活性的非核苷类逆转录酶抑制剂 (NNRTI)，具有强效的抗病毒活性。Capravirine 能够抑制对核苷/核苷酸逆转录酶抑制剂以及其他 NNRTI 耐药的 HIV-1 株的复制。Capravirine 通过细胞色素 P450 酶 CYP3A4 进行代谢。

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Capravirine Chemical Structure

Capravirine Chemical Structure

CAS No. : 178979-85-6

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Capravirine 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Capravirine (S-1153) is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) with potent antiviral activity. Capravirine inhibits replication of HIV-1 strains that are resistant to nucleoside/nucleotide reverse transcriptase inhibitors and other NNRTIs. Capravirine is metabolized by the cytochrome P450 enzyme CYP3A4[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MT2 EC50
0.2 nM
Compound: CPV
Antiviral activity against HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 10% FBS
Antiviral activity against HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 10% FBS
[PMID: 19104010]
分子量

451.37

Formula

C20H20Cl2N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Capravirine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Capravirine178979-85-6S-1153S1153S 1153Reverse TranscriptaseHIVHuman immunodeficiency virusorally activeNNRTIHIV-1nucleoside/nucleotide reverse transcriptase inhibitorsCYP3A4Inhibitorinhibitorinhibit

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