2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Dipeptidyl Peptidase P-glycoprotein
  4. Carmegliptin

Carmegliptin  (Synonyms: RO-4876904)

目录号: HY-10289
产品使用指南

摩尔计算器

Carmegliptin (RO-4876904) 是具有口服活性、效力强大且作用时间长的 dipeptidyl peptidase IV 抑制剂。Carmegliptin 也是 P-glycoprotein 的底物，与 Verapamil (HY-14275) 协同作用。Carmegliptin 可以改善高血糖小鼠的胰岛素敏感性，并减少肝脏葡萄糖生成。Carmegliptin 有望用于 2 型糖尿病，高血压和心血管疾病的研究。

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Carmegliptin Chemical Structure

Carmegliptin Chemical Structure

CAS No. : 813452-18-5

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Carmegliptin 相关抗体

Top Publications Citing Use of Products

查看 Dipeptidyl Peptidase 亚型特异性产品:

查看所有亚型
DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carmegliptin (RO-4876904) is an orally active, potent and long-acting dipeptidyl peptidase IV inhibitor. Carmegliptin is also a substrate of P-glycoprotein that synergizes with Verapamil (HY-14275). Carmegliptin improves insulin sensitivity and reduces hepatic glucose production in hyperglycemic mice. Carmegliptin is promising for research of type 2 diabetes, hypertension and cardiovascular disease[1][2].

IC50 & Target

DPP-4

 

分子量

377.45

Formula

C20H28FN3O3
CAS 号
中文名称

卡格列汀
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carmegliptin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carmegliptin813452-18-5RO-4876904卡格列汀RO4876904RO 4876904Dipeptidyl PeptidaseP-glycoproteinDPPP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243orally activedipeptidyl peptidase IVinsulinhepatic glucosehyperglycemic micediabetesInhibitorinhibitorinhibit

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