Carmoterol  (Synonyms: 卡莫特罗)

Carmoterol is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC₅₀ of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors^[1][2]. Carmoterol can be used for the research of asthma and chronic obstructive pulmonary disease (COPD)^[2].

Bronchoconstriction is induced in normal guinea-pigs by intravenous administration of graded doses of Acetylcholine (10, 20 and 40 mg/kg) and Histamine (5, 10 and 20 mg/kg) or in actively sensitized animals by Ovalbumin (5 mg/kg). Carmoterol (from 0.3 to 100 pmol) is given by superfusion onto the tracheal mucosa for 5 min before challenge. Carmoterol causes a dose-dependent inhibition of the acetylcholine-induced bronchoconstriction with the ED₅₀ of 16.7 pmol^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

368.43

C₂₁H₂₄N₂O₄

147568-66-9

卡莫特罗

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• [1]. Mario Cazzola, et al. β(2) -adrenoceptor agonists: current and future direction. Br J Pharmacol. 2011 May;163(1):4-17.  [Content Brief]

  [2]. Giuseppe Rossoni, et al. Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. Pulm Pharmacol Ther. 2007;20(3):250-7.  [Content Brief]