2. Anti-infection
  3. Penicillin-binding protein (PBP) Antibiotic Bacterial
  4. Carumonam

Carumonam  (Synonyms: AMA-1080; Ro 17-2301)

目录号: HY-121329
产品使用指南

摩尔计算器

Carumonam (AMA-1080; Ro 17-2301) 是一种磺化单环 β-内酰胺类抗生素，靶向青霉素结合蛋白 (penicillin-binding proteins, PBP)。Carumonam 对肠杆菌科、铜绿假单胞菌和流感嗜血杆菌具有高活性，对肺炎链球菌和金黄色葡萄球菌具有弱活性或无活性。Carumonam 对 β-内酰胺酶介导的水解具有抗性。

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Carumonam Chemical Structure

Carumonam Chemical Structure

CAS No. : 87638-04-8

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Customer Review

Other Forms of Carumonam:

Carumonam 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carumonam (AMA-1080; Ro 17-2301) is a sulfonated monocyclic β-Lactam Antibiotic, targeting to penicillin-binding protein (PBP). Carumonam exerts highly activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while it weakly and even inactively inhibits Streptococcus pneumoniae and Staphylococcus aureus. Carumonam is resistant to beta-lactamase-mediated hydrolysis[1].

IC50 & Target

β-lactam

 

体外研究
(In Vitro)

Carumonam 对肠杆菌科分离株的 MIC90 为 0.013-25 μg/mL，对铜绿假单胞菌的 MIC90 为 12.5 μg/mL[1]。
Carumonam (0-400 μg/mL) 对肠杆菌科和铜绿假单胞菌的 PBP-3 有高亲和力，IC50 与对应的 MIC 值相同或更小[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carumonam 相关抗体:
体内研究
(In Vivo)

Carumonam (20 mg/kg; 皮下注射或肌肉注射; 单剂量) 在小鼠、大鼠、兔子、狗和食蟹猴体内的药代动力学特征显示，它容易被吸收，在血浆、肾脏、肝脏和肺部的分布浓度高[2]。
动物: 5 周龄雄性 Slc:ICR 小鼠 (20-25 g)， 7 周龄雄性 Jcl:SD 大鼠 (210-250 g)，雄性新西兰大白兔 (2.5-3.5 kg)，雌雄比格犬 (10-15 kg)，雌性食蟹猴 (2.8-3.7 kg)。在使用抗生素之前，它们被剥夺饲料 16 至 18 小时；水被随意给予[2]。

药代动力学分析[2]

Animal Dose (mg/kg) Route Tmax (h) Cmax (μg/mL) AUC (μg·h/mL) t1/2 (h) CLp (mL/min/kg)
Mouse 2 mg/mL, 0.1 mL/10 g s.c. 0.12 40.7 20.0 0.24 16.7
Rat 10 mg/mL, 0.2 mL/100 g i.m. 0.18 37.9 23.9 0.28 14.0
Rabbit 40 mg/mL, 0.5 mL/kg i.m. 0.36 44.9 66.6 0.73 5.0
Dog 100 mg/mL, 0.2 mL/kg i.m. 0.36 36.3 61.1 1.10 5.5
Monkey 20 mg/mL/kg i.m. 0.29 67.9 80.4 0.89 4.5

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

466.40

Formula

C12H14N6O10S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carumonam 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carumonam87638-04-8AMA-1080 Ro 17-2301AMA1080AMA 1080Penicillin-binding protein (PBP)AntibioticBacterialInhibitorinhibitorinhibit

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