113137-57-8

生物活性：JMV 236是一种胆囊收缩素拮抗剂，具有抑制食欲的活性。JMV 236通过肠道内源性肽PrRP和CCK1受体的相互作用，影响食物摄入的调节。JMV 236的使用能激活位于NTS的PrRP神经元，从而加强其抑制食欲的效果。JMV 236对与食物摄入相关的中枢神经系统区域有显著影响，尤其是在饥饿状态下。

JMV 236 is a cholecystokinin antagonist with appetite-suppressing activity. JMV 236 affects the regulation of food intake through the interaction of the intestinal endogenous peptide PrRP and the CCK1 receptor. The administration of JMV 236 activates PrRP neurons located in the NTS, thereby enhancing its appetite-suppressing effect. JMV 236 has significant effects on areas of the central nervous system associated with food intake, especially during states of starvation^[1].