1781828-85-0

生物活性：(S)-Ro 32-0432 是一种有效的，选择性的，ATP 竞争性和具有口服活性的 PKC 抑制剂，对 PKCα，PKCβI，PKCβII，PKCγ 和 PKCε 的 IC₅₀ 值分别为 9.3 nM，28 nM，30 nM，36.5 nM 和 108.3 nM。(S)-Ro 32-0432 也是一种选择性 GRK5 的抑制剂。(S)-Ro 32-0432 可防止 T 细胞活化，并可用于慢性炎症和自身免疫性疾病的研究。

(S)-Ro 32-0432 is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC₅₀ values of (S)-Ro 32-0432 for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research^[1][2].