2108826-33-9

生物活性：UNC9994 hydrochloride 是一种功能选择性的 β-arrestin 偏向的多巴胺 D₂ 受体 (D₂R) 激动剂，可选择性激活 β- arresttin 招募和信号转导。对 D₂R 的 K_i 值为 79 nM。UNC9994 hydrochloride 也是 G_i 调节 cAMP 产生的拮抗剂和 D2R/β-arrestin-2 相互作用的部分激动剂。UNC9994 hydrochloride 具有稳定精神效果。

UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D₂ receptor (D₂R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a K_i of 79 nM for D₂R. UNC9994 hydrochloride is also an antagonist of G_i-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity^[1].