2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Cathepsin L/S-IN-1

Cathepsin L/S-IN-1 是 Cathepsin L 和 Cathepsin S 的双重抑制剂，IC50 分别为 4.10 μM 和 1.79 μM。Cathepsin L/S-IN-1 对胰腺癌 BxPC-3 和 PANC-1 细胞具有显著的抗转移和侵袭作用。

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Cathepsin L/S-IN-1 Chemical Structure

Cathepsin L/S-IN-1 Chemical Structure

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Cathepsin L/S-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells[1].

IC50 & Target[1]

cathepsin L

4.10 μM (IC50)

cathepsin S

1.79 μM (IC50)

体外研究
(In Vitro)

Cathepsin L/S-IN-1 (compound B1a) (0-25 μM; 48 h) shows noncytotoxic agaisnt pancreatic cancer BxPC-3 and PANC-1 cells[1].
Cathepsin L/S-IN-1 (0-25 μM; 48 h) inhibits Cathepsin L and S activities without decreasing the mRNA level of them[1].
Cathepsin L/S-IN-1 (0-25 μM; 48 h) inhibits the migration and invasion of pancreatic cancer BxPC-3 and PANC-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cathepsin L/S-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: BxPC-3 and PANC-1 cells
Concentration: 0, 6.25, 12.5, and 25 μM
Incubation Time: 48 hours
Result: Failed to suppress the viability of pancreatic cancer cells.
分子量

613.57

Formula

C29H33BrN4O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cathepsin L/S-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cathepsin L/S-IN-1CathepsinInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-152204
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