2. Anti-infection
  3. Antibiotic Bacterial
  4. Cefazolin sodium pentahydrate

Cefazolin sodium pentahydrate  (Synonyms: Cephazolin sodium pentahydrate)

目录号: HY-B0756
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摩尔计算器

Cefazolin sodium pentahydrate 是第一代头孢菌素类抗生素，可用于多种细菌感染的研究。Cefazolin sodium pentahydrate 具有抗炎作用，可以减轻术后认知功能障碍 (POCD)。

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Cefazolin sodium pentahydrate Chemical Structure

Cefazolin sodium pentahydrate Chemical Structure

CAS No. : 115850-11-8

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Cefazolin sodium pentahydrate 的其他形式现货产品:

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Other Forms of Cefazolin sodium pentahydrate:

Cefazolin sodium pentahydrate 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cefazolin sodium pentahydrate is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].

IC50 & Target

β-lactam

 

体外研究
(In Vitro)

Cefazolin sodium pentahydrate (0-300 μg/ml; 6 or 24 h) has a direct anti-inflammatory effect on C8-B4 cells stimulated by lipopolysaccharide[2].
Cefazolin sodium pentahydrate (0-400 μM; 72 h) treatment inhibits IL-2, IL-4 and IL-15-induced cell proliferation[3].
Cefazolin sodium pentahydrate (0-400 μM; 30 min) treatment inhibits IL-2, IL-4, IL-15 and IL-21-stimulated JAK3 phosphorylation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cefazolin sodium pentahydrate 相关抗体:

Cell Viability Assay[2]

Cell Line: C8-B4 cells
Concentration: 0, 50, 100, 150, 200, 250, or 300 μg/ml
Incubation Time: 6 or 24 hours
Result: Inhibited the increase of IL-1β at all doses, but inhibited the increase of IL-6 only at 200 μg/ml.

Cell Proliferation Assay[3]

Cell Line: PBMC, and TF-1 cells
Concentration: 0, 100, 200, and 400 μM
Incubation Time: 72 hours
Result: Reduced IL-2, IL-4 and IL-15-induced cell proliferation, suggested that Cefazolin interferes not only with IL-15Rα, but also with IL-2/IL-15Rβ and/or γc.

Western Blot Analysis[3]

Cell Line: PBMC, NK-92, and TF-1 cells
Concentration: 0, 100, 200, and 400 μM
Incubation Time: 30 min
Result: Diminished the phosphorylation of JAK3 in response to the cytokine treatment, concluded suppressing signal transduction by γc receptors.
体内研究
(In Vivo)

Cefazolin sodium pentahydrate (Subcutaneous injection; 300-500 mg/kg; once daily; 5 d) treatment improves learning and memory in mice after surgery[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6- to 8-week-old male CD-1 mice underwent clinical exploratory laparotomy[2]
Dosage: 300-500 mg/kg
Administration: Subcutaneous injection; 300-500 mg/kg; once daily; 5 days
Result: Attenuated learning and memory dysfunction induced by the surgery.
Clinical Trial
分子量

566.57

Formula

C14H23N8NaO9S3
CAS 号
中文名称

头孢唑啉五水合钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cefazolin sodium pentahydrate 相关分类

  • 摩尔计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefazolin sodium115850-11-8Cephazolin sodium头孢唑啉五水合钠AntibioticBacterialanti-inflammatory activitypost-operative cognitive dysfunctionPOCDC8-B4PBMCNK-92TF-1Inhibitorinhibitorinhibit

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