2. Anti-infection
  3. Antibiotic Bacterial
  4. Celastramycin A (isomer)

Celastramycin A isomer 是 Celastramycin A (HY-122292) 的异构体，Celastramycin A 是一种抗革兰氏阴性菌和结核杆菌的抗生素，MIC 为 0.05-3.1 μg/mL。Celastramycin A 通过免疫缺陷途径在离体果蝇中发挥免疫抑作用 (IC50 为 8 ng/mL)，通过 TNF-α 通路抑制人先天免疫反应，抑制 HUEVC 中 IL-8 的产生，IC50 为 60 ng/mL。

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Celastramycin A (isomer) Chemical Structure

Celastramycin A (isomer) Chemical Structure

CAS No. : 491600-94-3

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Other Forms of Celastramycin A (isomer):

Celastramycin A (isomer) 相关抗体

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生物活性

Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL[1][2].

分子量

390.69

Formula

C17H18Cl3NO3
CAS 号
结构分类
初始来源

Streptomyces strains
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Celastramycin A (isomer) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Celastramycin A (isomer)491600-94-3AntibioticBacterialInhibitorinhibitorinhibit

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