2. Anti-infection
  3. Antibiotic Bacterial
  4. Cephalochromin

Cephalochromin 是一种抗生素，也是细菌脂肪酸合酶 (FabI) 的抑制剂。Cephalochromin 可抑制 Staphylococcus aureus 和 Escherichia coli 的 FABI，IC50 为 1.9 和 1.8 μM。Cephalochromin 可抑制革兰氏阳性耐甲氧西林 S. aureus (MRSA) 和喹诺酮耐受的 S. aureus (QRSA)，MIC 为 2-8 µg/mL。

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Cephalochromin Chemical Structure

Cephalochromin Chemical Structure

CAS No. : 25908-26-3

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Cephalochromin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC50 of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
2.72 μM
Compound: Cephalochromin
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 24588135]
A549 IC50
5.22 μM
Compound: Cephalochromin
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 24588135]
BHK-21 IC50
20 μM
Compound: Cephalochromin
Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA
Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA
[PMID: 15387654]
Caco-2 IC50
12.4 μM
Compound: Cephalochromin
Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay
Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay
[PMID: 24588135]
Hep 3B2 IC50
14.31 μM
Compound: Cephalochromin
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
[PMID: 24588135]
HT-1080 IC50
4.98 μM
Compound: Cephalochromin
Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay
[PMID: 24588135]
Huh-7 IC50
4.64 μM
Compound: Cephalochromin
Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay
Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay
[PMID: 24588135]
SW1353 IC50
3.54 μM
Compound: Cephalochromin
Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay
Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay
[PMID: 24588135]
分子量

518.47

Formula

C28H22O10
CAS 号
结构分类
初始来源

Cephalosporium caerulens
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cephalochromin 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cephalochromin25908-26-3AntibioticBacterialStaphylococcus aureusMRSAQRSAEscherichia coliInhibitorinhibitorinhibit

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