2. GPCR/G Protein MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. Adenosine Receptor p38 MAPK Phosphodiesterase (PDE)
  4. CGH2466 dihydrochloride

CGH 2466 dihydrochloride 是一种具有口服活性的腺苷A1、A2B 和 A3 受体 (adenosine A1, A2B and A3 receptor) 拮抗剂，其 IC50 值分别为 19 nM、21 nM 和 80 nM。CGH 2466 dihydrochloride 抑制 p38 MAPK (IC50 = 187~400 nM) 和磷酸二酯酶 4D （IC50 = 22 nM）。CGH 2466 dihydrochloride 在体外和体内均显示出强大的抗炎作用，并可用于哮喘和慢性阻塞性肺病 (COPD) 的研究。

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CGH2466 dihydrochloride Chemical Structure

CGH2466 dihydrochloride Chemical Structure

CAS No. : 1177618-54-0

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CGH2466 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CGH 2466 dihydrochloride is an orally active adenosine A1, A2B and A3 receptor antagonist with the IC50 values of 19 nM, 21 nM, and 80 nM respectively. CGH 2466 dihydrochloride inhibits p38 MAPK (IC50 = 187~ 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 dihydrochloride displays potent anti-inflammatory effects both in vitro and in vivo, and can be used for research on asthma and chronic obstructive pulmonary disease (COPD)[1].

IC50 & Target

A1

19 nM (IC50)

A2B

21 nM (IC50)

A3

80 nM (IC50)

分子量

395.13

Formula

C14H11Cl4N3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CGH2466 dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGH24661177618-54-0CGH 2466CGH-2466Adenosine Receptorp38 MAPKPhosphodiesterase (PDE)P1 receptorasthmachronic obstructive pulmonary disease (COPD)Inhibitorinhibitorinhibit

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