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  3. Fungal Antibiotic
  4. Chitin synthase inhibitor 2

Chitin synthase inhibitor 2 是一种几丁质合酶 (chitin synthase) 抑制剂，IC50 为 0.09 mM, Ki 为 0.12 mM。Chitin synthase inhibitor 2 在体外具有抗菌活性，对 fluconazole 或 polyoxin B 具有协同或加性作用。

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Chitin synthase inhibitor 2 Chemical Structure

Chitin synthase inhibitor 2 Chemical Structure

CAS No. : 2416338-24-2

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Chitin synthase inhibitor 2 相关抗体

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生物活性

Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B[1].

IC50 & Target

IC50: 0.09 mM; Ki: 0.12 mM[1]
体外研究
(In Vitro)

Chitin synthase inhibitor 2 (compound 2b) (0, 0.032, 0.126, and 0.25 mM) inhibits chitin synthase with inhibition constant Ki value of 0.12 mM and the inhibition percent (IP) of 78.3% at 0.3 mM[1].
Chitin synthase inhibitor 2 (1-4 μg/mL) has excellent antifungal activity with MIC (minimum inhibitory concentration) values of 2, 4, 1, and 2 μg/mL against C. albicans (ATCC 76615), A. fumigatus (GIMCC 3.19), C. albicans (ATCC 90023), and A. flavus (ATCC 16870), respectively[1].
Chitin synthase inhibitor 2 (128-512 g/mL) has no antibacterial activity against MRSA (N. 315), S. aureus (ATCC 25923), B. subtilis (ATCC 6633), C. coli (JM 109), P. aeruginosa (ATCC 9027), and B. proteus (ATCC 8427) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chitin synthase inhibitor 2 相关抗体:
分子量

349.38

Formula

C20H19N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chitin synthase inhibitor 2 相关分类

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Keywords:

Chitin synthase inhibitor 22416338-24-2Chitin synthase inhibitor2Chitin synthase inhibitor-2FungalAntibioticfluconazolepolyoxin Bantifungal3,4-dihydro2(1H)-quinolinonequinolinonechitin synthaseCHSInhibitorinhibitorinhibit

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