2. Anti-infection PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis
  3. Antibiotic Bacterial Akt GSK-3 β-catenin c-Myc
  4. Chrysomycin A

Chrysomycin A  (Synonyms: Chr-A)

目录号: HY-126771
产品使用指南

摩尔计算器

Chrysomycin A (Chr-A) 是一种抗生素，能够来源于链霉菌。Chrysomycin A 表现出抗肿瘤和抗结核和 MRSA 活性。特别是在胶质母细胞瘤中，Chrysomycin A 通过 Akt/GSK-3β/β-catenin 信号通路抑制癌细胞的增殖、迁移和侵袭。

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Chrysomycin A Chemical Structure

Chrysomycin A Chemical Structure

CAS No. : 82196-88-1

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规格 价格 是否有货 数量
250 μg ￥2916
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Chrysomycin A 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 GSK-3 亚型特异性产品:

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GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway[1].

体外研究
(In Vitro)

Chrysomycin A (0.2-1.8 μM; 48 h) 具有抗胶质母细胞瘤作用，抑制 U251 和 U87-MG 人胶质母细胞瘤的细胞活力，以及迁移和侵袭[1]。
Chrysomycin A (0.2-1.8 μM; 48 h) 抑制 U251 和 U87-MG 细胞中 Akt/GSK-3β/β-Catenin 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chrysomycin A 相关抗体:

Cell Viability Assay[1]

Cell Line: U251 and U87-MG human glioblastoma
Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
Incubation Time: 48 hours
Result: Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively.

Western Blot Analysis[1]

Cell Line: U251 and U87-MG human glioblastoma
Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
Incubation Time: 48 hours
Result: Significantly downregulated the expression of slug and MMP2.
Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1.
分子量

508.52

Formula

C28H28O9
CAS 号
性状

固体

颜色

Light yellow to yellow

初始来源

marine-derived strain Streptomyces sp. 891
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献

Chrysomycin A 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chrysomycin A82196-88-1Chr-AAntibioticBacterialAktGSK-3β-cateninc-MycPKBProtein kinase BGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninMycInhibitorinhibitorinhibit

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