2. Anti-infection Cell Cycle/DNA Damage Apoptosis Metabolic Enzyme/Protease
  3. CMV DNA/RNA Synthesis Orthopoxvirus Apoptosis Endogenous Metabolite
  4. Cidofovir dihydrate

Cidofovir dihydrate  (Synonyms: 西多福韦二水合物; GS 0504 dihydrate; HPMPC dihydrate; (S)-HPMPC dihydrate)

目录号: HY-17438A
产品使用指南

摩尔计算器

Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate 是一种无环单磷酸核苷酸类似物，CMV 抑制剂，具有抗病毒活性。Cidofovir dihydrate 可通过选择性抑制病毒 DNA 聚合酶 (DNA polymerase) 来抑制巨细胞病毒 (CMV) 复制。Cidofovir dihydrate 可诱导细胞凋亡 (apoptosis)，用于巨细胞病毒性视网膜炎、疱疹、癌症研究。Cidofovir dihydrate 还具有抗正痘病毒 (orthopoxvirus) 和抗天花病毒活性。

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Cidofovir dihydrate Chemical Structure

Cidofovir dihydrate Chemical Structure

CAS No. : 149394-66-1

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规格 价格 是否有货 数量
5 mg ￥330
1 - 2 周
10 mg ￥450
1 - 2 周
50 mg ￥900
1 - 2 周
100 mg ￥1400
1 - 2 周
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Cidofovir dihydrate:

Cidofovir dihydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer[1][3]. Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities[4].

体外研究
(In Vitro)

Cidofovir (5-100 μM, 72 hours) dihydrate has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cells counts in a dose dependent manner[1].
Cidofovir (10-1000 μM, 24-120 hours) dihydrate can reduce cancer cell viability and induces apoptosis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cidofovir dihydrate 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Crandell-Reese feline kidney(CRFK) cells
Concentration: 10-100 μM
Incubation Time: 72 hours
Result: Reduced CRFK cells by 9.1%.

Cell Viability Assay[3]

Cell Line: Caco-2, FTC-133, HeLa, Hep-G2, MDA-MB-231, NCI-H1975 and PC-3 cells
Concentration: 10-1000 μM
Incubation Time: 24, 48, 72, 96, 120 hours
Result: Resulted in a gradual decrease in tumor cell viability with time and concentration increasing and inhibited the number of FTC-133 cell clones by about 55% at 100 μM comparing to the untreated group.

Apoptosis Analysis[3]

Cell Line: FTC-133 cells
Concentration: 100 μM
Incubation Time: 96 hours
Result: Showed a significant increase in the expression of pro-apoptotic proteins, such as cytochrome c, phospho-p53 (S15) and caspase-3 by 130%, 49%, and 46%, respectively while the anti-apoptotic protein Bcl-x decreased significantly by 57% comparing to the untreated cells.
体内研究
(In Vivo)

Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) dihydrate is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female weanling BALB/c mice infected with cowpox virus (CPV)[2]
Dosage: 100 mg/kg
Administration: Subcutaneous injection; 3-6 days interval; 21 days
Result: Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection.
Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day.
Clinical Trial
分子量

315.22

Formula

C8H18N3O8P
CAS 号
中文名称

西多福韦二水合物；昔多呋韦二水合物
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cidofovir dihydrate 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cidofovir dihydrate149394-66-1GS 0504 dihydrateHPMPC dihydrate(S)-HPMPC dihydrate西多福韦二水合物昔多呋韦二水合物CMVDNA/RNA SynthesisOrthopoxvirusApoptosisEndogenous MetaboliteCytomegalovirusantiviralcytomegalovirusretinitisherpescancerInhibitorinhibitorinhibit

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