2. Protein Tyrosine Kinase/RTK
  3. PDGFR VEGFR
  4. cis-SU4312

cis-SU4312 ((Z)-SU4312) 抑制 PDGFR 和 FLK-1，IC50 分别为 19.4 和 0.8 μM。cis-SU4312 抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R，IC50 分别为 24.2，5.2，18.5，16.9 和 10.0 μM。cis-SU4312 能透过血脑屏障。

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cis-SU4312 Chemical Structure

cis-SU4312 Chemical Structure

CAS No. : 90828-16-3

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规格 价格 是否有货 数量
1 mg ￥1701
1 - 2 周
5 mg ￥3850
1 - 2 周
10 mg ￥5698
1 - 2 周
25 mg 现货 1 - 2 周
50 mg 现货 1 - 2 周
100 mg   询价  
200 mg   询价  

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Other Forms of cis-SU4312:

cis-SU4312 相关抗体

Top Publications Citing Use of Products

查看 PDGFR 亚型特异性产品:

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PDGFR PDGFRβ PDGFRα

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

cis-SU4312 ((Z)-SU4312) inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. cis-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively. cis-SU4312 can cross blood brain barrier[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SF-539 IC50
3.7 μM
Compound: 22, DMBI
Inhibition of PDGFRbeta in human SF539 cells assessed as inhibition of PDGFR-BB-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation measured 10 mins by ELISA
Inhibition of PDGFRbeta in human SF539 cells assessed as inhibition of PDGFR-BB-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation measured 10 mins by ELISA
[PMID: 23434139]
SF-539 IC50
3.7 μM
Compound: 50, DMBI
Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA
Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA
[PMID: 20403700]
SF-539 IC50
3.75 μM
Compound: 21, DMBI
Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISA
Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISA
[PMID: 22204741]
SF-539 IC50
3.75 μM
Compound: 19, SU-4312
Inhibition of PDGFRbeta in human SF539 cells pretreated for 60 mins measured after 1 hr by ELISA
Inhibition of PDGFRbeta in human SF539 cells pretreated for 60 mins measured after 1 hr by ELISA
[PMID: 22739090]
SF-539 IC50
3.75 μM
Compound: DMBI
Inhibition of PDGFRbeta in human SF539 cells by phosphotyrosine cell-based ELISA
Inhibition of PDGFRbeta in human SF539 cells by phosphotyrosine cell-based ELISA
[PMID: 20092323]
分子量

264.32

Formula

C17H16N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

cis-SU4312 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-SU431290828-16-3(Z)-SU4312PDGFRVEGFRPlatelet-derived growth factor receptorVascular endothelial growth factor receptorSU4312isomerInhibitorinhibitorinhibit

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目录号：
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