CLEFMA 

CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects^[1][2].

CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity^[1].
CLEFMA inhibits the viability of H441 and A549 cells, with IC₅₀s of 6.4 and 8.9 μM, respectively^[2].
CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells^[2].
CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells^[1].
CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model^[2].
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

442.29

C₂₃H₁₇Cl₂NO₄

1246964-32-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lagisetty P, et, al. CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones. Bioorg Med Chem. 2010 Aug 15; 18(16):6109-20.  [Content Brief]

  [2]. Yadav VR, et, al. Preclinical evaluation of 4-[3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl]-4-oxo-2-butenoic acid, in a mouse model of lung cancer xenograft. Br J Pharmacol. 2013 Dec; 170(7): 1436-48.  [Content Brief]