2. Apoptosis
  3. Apoptosis
  4. CLEFMA

CLEFMA 是一种具有抗肿瘤活性的姜黄素。CLEFMA 抑制肿瘤生长与 NF-κB 调节的抗炎和抗转移作用有关。

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CLEFMA Chemical Structure

CLEFMA Chemical Structure

CAS No. : 1246964-32-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥10752
In-stock
1 mg ￥2210
In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

CLEFMA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
NCI-H441 IC50
1 μM
Compound: 29, CLEFMA
Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs
Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs
[PMID: 20638855]
体外研究
(In Vitro)

CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity[1].
CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2].
CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells[2].
CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells[1].
CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CLEFMA 相关抗体:

Cell Proliferation Assay[1]

Cell Line: PANC-1, MiaPaCa-2, PC-3 and H441 cells
Concentration: 1, 10, 25, 100 μM
Incubation Time: 24, 48, 72 h
Result: Inhibits cells proliferation in a dose-dependent manner.
体内研究
(In Vivo)

CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model[2].
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nu/nu mice (4 weeks old) are injected H441 cells[2]
Dosage: 0.2, 0.4 mg/kg
Administration: I.p. daily for 4 weeks
Result: Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.
分子量

442.29

Formula

C23H17Cl2NO4
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 116.67 mg/mL (263.79 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2610 mL 11.3048 mL 22.6096 mL
5 mM 0.4522 mL 2.2610 mL 4.5219 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

CLEFMA 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2610 mL 11.3048 mL 22.6096 mL 56.5240 mL
5 mM 0.4522 mL 2.2610 mL 4.5219 mL 11.3048 mL
10 mM 0.2261 mL 1.1305 mL 2.2610 mL 5.6524 mL
15 mM 0.1507 mL 0.7537 mL 1.5073 mL 3.7683 mL
20 mM 0.1130 mL 0.5652 mL 1.1305 mL 2.8262 mL
25 mM 0.0904 mL 0.4522 mL 0.9044 mL 2.2610 mL
30 mM 0.0754 mL 0.3768 mL 0.7537 mL 1.8841 mL
40 mM 0.0565 mL 0.2826 mL 0.5652 mL 1.4131 mL
50 mM 0.0452 mL 0.2261 mL 0.4522 mL 1.1305 mL
60 mM 0.0377 mL 0.1884 mL 0.3768 mL 0.9421 mL
80 mM 0.0283 mL 0.1413 mL 0.2826 mL 0.7065 mL
100 mM 0.0226 mL 0.1130 mL 0.2261 mL 0.5652 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLEFMA1246964-32-8Apoptosiscurcuminoid antitumorNF-κB-regulatedanti-inflammatoryanti-metastaticcancerInhibitorinhibitorinhibit

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