2. Anti-infection
  3. Bacterial Antibiotic
  4. Clindamycin hydrochloride monohydrate

Clindamycin hydrochloride monohydrate 

目录号: HY-N7118
产品使用指南 技术支持

Clindamycin hydrochloride monohydrate 是一种口服有效的蛋白质合成抑制剂，其具有以亚抑制浓度 (sub-MICs) 在金黄色葡萄球菌中毒力因子表达的能力。Clindamycin hydrochloride monohydrate 的抗性是由 50S 核糖体亚基 (23S rRNA) 中抗生素结合位点的酶促甲基化产生。Clindamycin hydrochloride monohydrate 能降低杀白细胞毒素 (PVL)、毒性休克-葡萄球菌毒素 (TSST-1) 或 α-溶血素 (Hla) 的产生。

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Clindamycin hydrochloride monohydrate Chemical Structure

Clindamycin hydrochloride monohydrate Chemical Structure

CAS No. : 58207-19-5

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Clindamycin hydrochloride monohydrate 的其他形式现货产品:

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Clindamycin hydrochloride monohydrate 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B-cell IC50
> 400 μM
Compound: Clindamycin
Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
[PMID: 19075064]
HeLa IC50
> 400 μg/mL
Compound: Clindamycin
Antiproliferative effect against HeLa cells after 48 hrs
Antiproliferative effect against HeLa cells after 48 hrs
[PMID: 17088489]
HeLa IC50
200 μg/mL
Compound: Clindamycin
Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs
[PMID: 17088489]
MG-63 IC50
> 400 μg/mL
Compound: Clindamycin
Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs
[PMID: 17088489]
MG-63 IC50
250 μg/mL
Compound: Clindamycin
Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs
Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs
[PMID: 17088489]
Osteoblast IC50
> 400 μg/mL
Compound: Clindamycin
Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs
[PMID: 17088489]
Osteoblast IC50
150 μg/mL
Compound: Clindamycin
Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs
Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs
[PMID: 17088489]
Clinical Trial
分子量

479.46

Formula

C18H36Cl2N2O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Clindamycin hydrochloride monohydrate 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clindamycin hydrochloride58207-19-5BacterialAntibioticInhibitorinhibitorinhibit

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