2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Coleon-U-quinone

Coleon-U-quinone 是一种有效的 P-gp 抑制剂。Coleon-U-quinone 能抑制癌细胞活力，能提高多药耐药肿瘤细胞对 Doxorubicin (HY-15142A) 的敏感性。

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Coleon-U-quinone Chemical Structure

Coleon-U-quinone Chemical Structure

CAS No. : 65714-83-2

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Coleon-U-quinone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A)[1].

IC50 & Target

P-glycoprotein[1]
体外研究
(In Vitro)

Coleon-U-quinone (0-50 μM; 72 h) has inhibitory activity against NCI-H460, NCI-H460/R and MRC-5[1].
Coleon-U-quinone (1-5 μM; 72 h) sensitize NCI-H460/R cells to Doxorubicin (HY-15142A)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Coleon-U-quinone 相关抗体:

Cell Viability Assay[1]

Cell Line: NCI-H460, NCI-H460/R and MRC-5
Concentration: 0-50 μM
Incubation Time: 72 h
Result: Exhibited inhibitory activity against NCI-H460, NCI-H460/R and MRC-5 with IC50s of 22.96 ± 0.56 μM, 20.37 ± 0.43 μM and 44.13 ± 1.19 μM.

Cell Proliferation Assay[1]

Cell Line: NCI-H460/R
Concentration: 1, 2 and 5 μM
Incubation Time: 72 h
Result: Sensitized NCI-H460/R cells to Doxorubicin (HY-15142A) with IC50s of 0.565 μM, 0.482 μM and 0.217 μM at 1 μM, 2 μM and 5 μM, respectively.
分子量

344.40

Formula

C20H24O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Coleon-U-quinone 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coleon-U-quinone65714-83-2P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243multidrug resistanceanticancerDoxorubicinNCI-H460NCI-H460/RMRC-5Inhibitorinhibitorinhibit

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