2. Anti-infection
  3. Antibiotic Bacterial
  4. Colistin

Colistin  (Synonyms: 抗敌素; Polymyxin E)

目录号: HY-113678
产品使用指南

摩尔计算器

Colistin (Polymyxin E) 是一种多肽抗生素，具有口服活性。Colistin 对多种革兰氏阴性杆状细菌(包括多重耐药的铜绿假单胞菌、鲍曼不动杆菌和肺炎克雷伯菌)等均有良好的抑制活性。Colistin 与肾毒性有关，可用于革兰氏阴性菌感染的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Colistin sulfate 通常具有更好的水溶性和稳定性。

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Colistin Chemical Structure

Colistin Chemical Structure

CAS No. : 1066-17-7

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Colistin 的其他形式现货产品:

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Colistin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Colistin (Polymyxin E) is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli[1][2].

体内研究
(In Vivo)

Colistin (Polymyxin E) (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice[1]
Dosage: 16 mg/kg/day
Administration: 16 mg/kg/day, i.p.
Result: Detected apoptosis, necrosis PCNA staining in mice.
Clinical Trial
分子量

1169.50

Formula

C53H100N16O13 (for E1)
CAS 号
中文名称

抗敌素，多黏菌素E
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Colistin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Colistin1066-17-7Polymyxin E抗敌素，多黏菌素EAntibioticBacterialoralpolypeptide antibioticPseudomonas aeruginosaKlebsiella pneumoniaeAcinetobacter baumanniiGram-negative bacterianephrotoxicityinfectionInhibitorinhibitorinhibit

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