2. GPCR/G Protein
  3. GHSR
  4. Cortistatin-8

Cortistatin-8 (CST-8; PCFWKTCK) 是一种神经肽，是一种 GHS-R1a 拮抗剂，可抵消生长素释放肽对胃酸分泌的反应，并在体外调节生长激素细胞的生长素释放。Cortistatin-8 是一种合成的 CST 类似物，对 SST-R 没有任何结合亲和力，但能够结合 GHS-R1a。Cortistatin-8 可在动物体内或体外对生长素释放肽作用产生拮抗作用。

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Custom Peptide Synthesis

Cortistatin-8 Chemical Structure

Cortistatin-8 Chemical Structure

CAS No. : 485803-62-1

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Cortistatin-8 相关抗体

Top Publications Citing Use of Products

查看 GHSR 亚型特异性产品:

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GHSR1a

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1].

IC50 & Target[1]

GHSR1a

 

分子量

1009.25

Formula

C47H68N12O9S2
CAS 号
Sequence

Pro-Cys-Phe-{d-Trp}-Lys-Thr-Cys-Lys-NH2 (disulfide bridge: Cys2-Cys7)
Sequence Shortening

PCF-{d-Trp}-WKTCK-NH2 (disulfide bridge: Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cortistatin-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cortistatin-8485803-62-1PCFWKTCKCortistatin8Cortistatin 8GHSRGrowth hormone secretagogue receptorGhrelin receptorneuropeptideCSTSST-RGHS-R1aghrelingastric acid secretion andin vitroto modulate GH release from somatotroph cellInhibitorinhibitorinhibit

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目录号：
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