2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Cosibelimab

Cosibelimab  (Synonyms: 柯希利单抗; CK-301; TG-1501)

目录号: HY-P99833 纯度: 99.90%
COA 技术支持

Cosibelimab(CK-301; TG-1501)是一种高亲和力、全人源 PD-L1 阻断单克隆抗体，可结合 PD-L1 并阻断其与 PD-1 的相互作用。Cosibelimab 具有功能性 Fc 结构域，能够诱导 ADCC 和补体依赖性细胞毒性 (CDC) 介导的 PD-L1+ 细胞系杀伤，包括淋巴瘤细胞。

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CAS No. : 2216751-26-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Cosibelimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cosibelimab (CK-301; TG-1501) is a high-affinity, fully human PD-L1-blocking monoclonal antibody that binds PD-L1 and blocks its interaction with PD-1. Cosibelimab has a functional Fc domain and is capable of inducing ADCC and complement-dependent cytotoxicity (CDC)-mediated killing of PD-L1+ cell lines, including lymphoma cells[1].

同型

Human IgG1 lambda1
推荐同型对照抗体
种属

Human
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

柯希利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Biological Activity
  • Immobilized PD-L1 Protein, Human can bind Cosibelimab. The EC50 for this effect is 18.75 ng/mL.
纯度 & 产品资料

纯度: 99.90%

COA (264 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Cosibelimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cosibelimab2216751-26-5CK-301 TG-1501柯希利单抗CK301CK 301TG1501TG 1501TG-1501PD-1/PD-L1PD-1/Programmed death-ligand 1PD-L1PD-1Fc domainlymphomaInhibitorinhibitorinhibit

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