2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK
  4. CP-690550A

CP-690550A 是 Tofacitinib (HY-40354) 的类似物。CP-690550A 是 JAK2 和 JAK3 的双重抑制剂。

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CP-690550A Chemical Structure

CP-690550A Chemical Structure

CAS No. : 1243290-37-0

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CP-690550A 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-690550A is an analogue of Tofacitinib (HY-40354). CP-690550A is a dual inhibitor of JAK2 and JAK3[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
32 nM
Compound: 17d
Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA
Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA
[PMID: 21105711]
Sf9 IC50
480 nM
Compound: 17d
Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISA
Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISA
[PMID: 21105711]
Sf9 IC50
840 nM
Compound: 17d
Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA
Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA
[PMID: 21105711]
T-cell IC50
450 nM
Compound: 17d
Inhibition of human IL2-dependent T cell blast proliferation assessed as reduction in [3H]thymidine incorporation after 72 hrs post dose IL2 blast assay
Inhibition of human IL2-dependent T cell blast proliferation assessed as reduction in [3H]thymidine incorporation after 72 hrs post dose IL2 blast assay
[PMID: 21105711]
分子量

303.36

Formula

C15H21N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP-690550A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-690550A1243290-37-0JAKJanus kinaseJAK3inflammatorymyeloproliferative diseasesInhibitorinhibitorinhibit

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产品名称：
CP-690550A
目录号：
HY-123289
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