2. Autophagy Protein Tyrosine Kinase/RTK
  3. Autophagy PDGFR FLT3
  4. Crenolanib benzenesulfonate

Crenolanib benzenesulfonate  (Synonyms: CP 868596-26)

目录号: HY-13223A
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摩尔计算器

Crenolanib benzenesulfonate 是有效和选择性的野生型和突变型 III 类受体酪氨酸激酶抑制剂，抑制 FLT3 和 PDGFRα/β 的 Kd 分别为 0.74 nM，2.1 nM，3.2 nM。

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Crenolanib benzenesulfonate Chemical Structure

Crenolanib benzenesulfonate Chemical Structure

CAS No. : 670220-93-6

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Crenolanib benzenesulfonate 的其他形式现货产品:

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Other Forms of Crenolanib benzenesulfonate:

Crenolanib benzenesulfonate 相关抗体

Top Publications Citing Use of Products

    Crenolanib benzenesulfonate purchased from MCE. Usage Cited in: Glia. 2020 Feb;68(2):345-355.  [Abstract]

    Western blots of PDGFRα and NG2 in slices treated with CP673451 and Crenolanib for 9 days.

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    PDGFR PDGFRβ PDGFRα

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Crenolanib benzenesulfonate is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively.

    IC50 & Target

    Kd: 2.1 nM (PDGFRα), 3.2 nM (PDGFRβ), 0.74 nM (FLT3)
    分子量

    601.72

    Formula

    C32H35N5O5S
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Crenolanib benzenesulfonate 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Crenolanib670220-93-6CP 868596-26AutophagyPDGFRFLT3Platelet-derived growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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