2. Immunology/Inflammation
  3. P-selectin
  4. Crizanlizumab

Crizanlizumab  (Synonyms: 立赞利珠单抗)

目录号: HY-P9987 纯度: ≥95.0%
COA

摩尔计算器

Crizanlizumab 是一种抗-P-选择素 (P-selectin) 单克隆抗体。Crizanlizumab 可与 P-选择素结合并阻断其与 P-选择素糖蛋白配体 1 (PSGL-1) 的相互作用。Crizanlizumab 可阻止血管阻塞性危象 (VOC)，可用于镰状细胞病的研究。

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CAS No. : 1690318-25-2

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规格 价格 是否有货 数量
1 mg ￥5200
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Crizanlizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease[1][2][3].

同型

Human IgG2 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target

P-selectin[2]
体内研究
(In Vivo)

Crizanlizumab (1 或 6 mg/kg，腹膜内注射，每周 3 天，持续 5 个月) 可改善 4 周龄雄性 HbSS (镰状细胞病) 小鼠的镰状细胞性视网膜病变[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

立赞利珠单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
纯度 & 产品资料

纯度: ≥95.0%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Crizanlizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Crizanlizumab1690318-25-2立赞利珠单抗P-selectinCD62Sickle cell diseaseVOCsvaso-occlusive criseHbSS miceInhibitorinhibitorinhibit

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