2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Crobenetine hydrochloride

Crobenetine hydrochloride  (Synonyms: BIII-890 hydrochloride; BIII-890 CL)

目录号: HY-16923A
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摩尔计算器

Crobenetine hydrochloride (BIII-890 hydrochloride) 是 Crobenetine (HY-16923) 的盐酸盐形式。Crobenetine hydrochloride 是 Na+ 通道 (Na+ channel) 抑制剂。Crobenetine hydrochloride 在大鼠脑突触体中取代 Na+ 通道位点 2 的 3HBTX (IC50=49 nM)，但对其他受体和离子通道仅表现出较低的结合亲和力。Crobenetine hydrochloride 可保护啮齿动物的脑组织免受局灶性脑缺血的有害影响。

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Crobenetine hydrochloride Chemical Structure

Crobenetine hydrochloride Chemical Structure

CAS No. : 221018-88-8

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Other Forms of Crobenetine hydrochloride:

Crobenetine hydrochloride 相关抗体

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生物活性

Crobenetine hydrochloride (BIII-890 hydrochloride) is the hydrochloride form of Crobenetine (HY-16923). Crobenetine hydrochloride is a selective inhibitor for Na+ channel. Crobenetine hydrochloride displaces 3HBTX from site 2 of the Na+ channel (IC50=49 nM) in rat brain synaptosomes, exhibits only low binding affinity for other receptors and ion channels. Crobenetine hydrochloride protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents[1].

分子量

416.00

Formula

C25H34ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Crobenetine hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crobenetine221018-88-8BIII-890 BIII-890 CLBIII890BIII 890Sodium ChannelNa channelsNa+ channelsBenzomorphanBTXbrain synaptosomesdeleteriousfocal cerebral ischemiaInhibitorinhibitorinhibit

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