1. Immunology/Inflammation
  2. COX
  3. Cyclovalone

Cyclovalone (Beveno) 是一种合成姜黄素衍生物,可抑制环氧合酶 (cyclooxygenase) 并具有抗炎、抗肿瘤和抗氧化活性。Cyclovalone 抑制正常和恶性前列腺细胞的增殖。Cyclovalone 具有口服活性。

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Cyclovalone Chemical Structure

Cyclovalone Chemical Structure

CAS No. : 579-23-7

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1 mg ¥880
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclovalone (Beveno) is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities[1]. Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active[2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CNE IC50
17.6 μM
Compound: C2
Cytotoxicity against human CNE cells after 72 hrs by MTT assay
Cytotoxicity against human CNE cells after 72 hrs by MTT assay
[PMID: 19243951]
HEK293 EC50
2.6 μM
Compound: 3a
Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells after 24 hrs by firefly/renilla dual luciferase reporter gene assay
Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells after 24 hrs by firefly/renilla dual luciferase reporter gene assay
[PMID: 24275249]
HL-60 IC50
< 10.1 μM
Compound: C2
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 19243951]
HT-29 IC50
3.73 μM
Compound: A7
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 22551677]
KB CC50
6.7 μM
Compound: 7a
Compound concentration required to reduce the exponential growth of KB cells by 50%
Compound concentration required to reduce the exponential growth of KB cells by 50%
[PMID: 9767632]
LS174T IC50
4.6 μM
Compound: C2
Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay
Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay
[PMID: 19243951]
MDA-MB-231 EC50
2.6 μM
Compound: A13,BMHPC
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
[PMID: 20728364]
MT4 CC50
2.4 μM
Compound: 7a
Compound concentration required to reduce the exponential growth of MT-4 cells by 50%
Compound concentration required to reduce the exponential growth of MT-4 cells by 50%
[PMID: 9767632]
PANC-1 IC50
4.43 μM
Compound: A7
Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay
Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay
[PMID: 22551677]
PC-3 IC50
5.89 μM
Compound: A7
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
[PMID: 22551677]
RAW264.7 IC50
6.68 μM
Compound: 8
Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced nitric oxide production after 17 to 20 hr by Griess assay
Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced nitric oxide production after 17 to 20 hr by Griess assay
10.1007/s00044-010-9521-0
THP-1 IC50
> 200 nM
Compound: 1d
Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagulant activity incubated for 1 hr prior to LPS-challenge measured after 5 hr by spectrophotometric analysis
Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagulant activity incubated for 1 hr prior to LPS-challenge measured after 5 hr by spectrophotometric analysis
10.1007/s00044-012-0330-5
体外研究
(In Vitro)

Cyclovalone (0.2-10 μg/ml) 通过干扰细胞周期转变来抑制雄激素反应性 LNCaP 细胞和雄激素非依赖性 PC-3 细胞的增殖[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 0.2-10 μg/ml
Incubation Time: 2-9 days
Result: Inihibited cell proliferation in LNCaP and PC-3 cells in a time- and dose-dependent manner.

Cell Cycle Analysis[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 2 μg/ml
Incubation Time: 72 h
Result: Decreased the numbers of LNCaP cells in G0/G1 phase, increased the numbers of cells in S-phase and G2/M phase.
Decreased the numbers of PC-3 cells in G0/G1 phase, increased the numbers of cells in S-phase.
体内研究
(In Vivo)

Cyclovalone (9.5-38 mg/kg,口服 14 天) 是一种前列腺特异性拮抗剂,对 BALB/c 小鼠没有明显毒性[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[2]
Dosage: 9.5-38 mg/kg/day
Administration: p.o. for 14 days
Result: Reduced weight of ventral prostate in a dose-dependent manner.
Animal Model: PC-3 xenografted athymic BALB/c nude mice[2]
Dosage: 38 mg/kg
Administration: p.o. for 20 days
Result: Inhibited tumor growth without toxicity.
分子量

366.41

Formula

C22H22O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Cyclovalone
目录号:
HY-107336
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