2. Immunology/Inflammation
  3. COX
  4. Cyclovalone

Cyclovalone  (Synonyms: Beveno)

目录号: HY-107336
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摩尔计算器

Cyclovalone (Beveno) 是一种合成姜黄素衍生物，可抑制环氧合酶 (cyclooxygenase) 并具有抗炎、抗肿瘤和抗氧化活性。Cyclovalone 抑制正常和恶性前列腺细胞的增殖。Cyclovalone 具有口服活性。

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Cyclovalone Chemical Structure

Cyclovalone Chemical Structure

CAS No. : 579-23-7

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Cyclovalone 相关抗体

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclovalone (Beveno) is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities[1]. Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active[2].

体外研究
(In Vitro)

Cyclovalone (0.2-10 μg/ml) 通过干扰细胞周期转变来抑制雄激素反应性 LNCaP 细胞和雄激素非依赖性 PC-3 细胞的增殖[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclovalone 相关抗体:

Cell Proliferation Assay[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 0.2-10 μg/ml
Incubation Time: 2-9 days
Result: Inihibited cell proliferation in LNCaP and PC-3 cells in a time- and dose-dependent manner.

Cell Cycle Analysis[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 2 μg/ml
Incubation Time: 72 h
Result: Decreased the numbers of LNCaP cells in G0/G1 phase, increased the numbers of cells in S-phase and G2/M phase.
Decreased the numbers of PC-3 cells in G0/G1 phase, increased the numbers of cells in S-phase.
体内研究
(In Vivo)

Cyclovalone (9.5-38 mg/kg，口服 14 天) 是一种前列腺特异性拮抗剂，对 BALB/c 小鼠没有明显毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[2]
Dosage: 9.5-38 mg/kg/day
Administration: p.o. for 14 days
Result: Reduced weight of ventral prostate in a dose-dependent manner.
Animal Model: PC-3 xenografted athymic BALB/c nude mice[2]
Dosage: 38 mg/kg
Administration: p.o. for 20 days
Result: Inhibited tumor growth without toxicity.
分子量

366.41

Formula

C22H22O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cyclovalone 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclovalone579-23-7BevenoCOXCyclooxygenaseathymic nude miceLNCaPPC-3Inhibitorinhibitorinhibit

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