2. Protein Tyrosine Kinase/RTK
  3. Discoidin Domain Receptor
  4. DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride是DDR1受体酪氨酸激酶抑制剂，IC50 值为105 nM，而对 DDR2 的 IC50 为413 nM。

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DDR1-IN-1 dihydrochloride Chemical Structure

DDR1-IN-1 dihydrochloride Chemical Structure

CAS No. : 1780303-76-5

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DDR1-IN-1 dihydrochloride 的其他形式现货产品:

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Other Forms of DDR1-IN-1 dihydrochloride:

DDR1-IN-1 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Discoidin Domain Receptor 亚型特异性产品:

查看所有亚型
DDR1 DDR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1].

IC50 & Target

DDR1

105 nM (IC50)

DDR2

413 nM (IC50)

体外研究
(In Vitro)

DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DDR1-IN-1 dihydrochloride 相关抗体:
分子量

625.51

Formula

C30H33Cl2F3N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DDR1-IN-1 dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

DDR1-IN-11780303-76-5Discoidin Domain ReceptorInhibitorinhibitorinhibit

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产品名称：
DDR1-IN-1 dihydrochloride
目录号：
HY-13979A
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